Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells.

Death in Human Gastric Epithelial Cells Oxidative Stress and Programmed Cell Infection Induces Helicobacter pylori

Helicobacter pylori infection induces oxidative stress and programmed cell death 2 in human gastric epithelial cells 3 4 5

24 Helicobacter pylori infection is associated with altered gastric epithelial cell turnover. To evaluate 25 the role of oxidative stress in cell death, gastric epithelial cells were exposed to various strains of H. 26 pylori, inflammatory cytokines and hydrogen peroxide in the absence or presence of antioxidant 27 agents. Increased intracellular reactive oxygen species (ROS) were detected usin...

Pathogenic interactions between Helicobacter pylori adhesion protein HopQ and human cell surface adhesion molecules CEACAMs in gastric epithelial cells

Objective(s): The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori.Materials and Methods: The literature was searched on “PubMed” using different key words including Helicobacter pylori, CEACAM and gastric.<br ...

Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection.

Human apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzyme involved in repair of oxidative DNA base damage, is an important transcriptional coregulator. We previously reported that Helicobacter pylori infection induces apoptosis and increases APE-1 expression in human gastric epithelial cells (GEC). Although both the DNA repair activity and the acetylation-mediated transcriptional regulat...

Induction of gastric epithelial apoptosis by Helicobacter pylori.

BACKGROUND Helicobacter pylori may promote gastric carcinogenesis through increasing gastric epithelial cell proliferation. How H pylori does so is unknown. Programmed, non-necrotic, cell death (apoptosis) occurs throughout the gut and is linked to proliferation. It was hypothesised that H pylori may induce hyper-proliferation through increasing apoptosis. AIM To measure the effect of H pylor...